Research News

New Breast Cancer Research funded undergraduate medical students starting their Summer Research Programme at the Lambe Institute for Translational Research. L-R: Mohamed Elhadi, Kumaraguru Muthu, Fergus McCabe, Eoin Coughlan, Ciara Ryan, Céire Burke, Erin Naughton, Christine Costelloe (Development Director of Breast Cancer Research), Eoghan O’Leary, Andrea Grealish

New Breast Cancer Research funded undergraduate medical students starting their Summer Research Programme at the Lambe Institute for Translational Research. L-R: Mohamed Elhadi, Kumaraguru Muthu, Fergus McCabe, Eoin Coughlan, Ciara Ryan, Céire Burke, Erin Naughton, Christine Costelloe (Development Director of Breast Cancer Research), Eoghan O’Leary, Andrea Grealish

A huge welcome to the new Breast Cancer Research funded undergraduate medical students starting their Summer Research Programme at the Lambe Institute for Translational Research. The research students have just begun their eight-week research internship and will present their findings at the School of Medicine Undergraduate Research Day later in October.

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Breast Cancer Research funds the work of the research team at the Lambe Institute for Translational Research. We are pleased to share the following recent achievements made by the team.

donald courtney_soh2016Dr Donald Courtney, a MD Student, supervised by Prof Michael Kerin, won the poster prize at the 24th Sylvester O’Halloran Perioperative Scientific Symposium in Limerick on 5 March 2016 for his research entitled Comparative Analysis of Adipose Derived Stem Cells from breast tissue and mesenchymal stem cells by Immunophenotyping. Congratulations to Donald!
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The Research Team has recently published the following:
Dr Doireann Joyce published a paper in the International Journal of Cancer on her exosome research.
Title: Exosome-encapsulated microRNAs as circulating biomarkers for breast cancer.
Authors: Joyce DP, Kerin MJ, Dwyer RM.
Journal Details: Int J Cancer. 2016 May 11. doi: 10.1002/ijc.30179. [Epub ahead of print] Review.

Professor Michael Kerin and Dr Nicola Miller collaborated on a paper that was published in Oncogene.
Title: NCOA3 coactivator is a transcriptional target of XBP1 and regulates PERK-eIF2α-ATF4 signalling in breast cancer. Authors: Gupta A, Hossain MM, Miller N, Kerin M, Callagy G, Gupta S.
Journal Details: Oncogene. 2016 Apr 25. doi: 10.1038/onc.2016.121. [Epub ahead of print]

The clinical breast cancer team at the Symptomatic Breast Unit published a report on breast reconstruction.
Title: Influence of complications following immediate breast reconstruction on breast cancer recurrence rates.
Authors: Beecher SM, O’Leary DP, McLaughlin R, Sweeney KJ, Kerin MJ.
Journal Details: Br J Surg. 2016 Mar;103(4):391-8. doi: 10.1002/bjs.10068.


 

Una Mc Veigh_18April19 April 2016: Well done to Úna McVeigh, a Ph.D. student at NUI Galway, who was the third prize winner in the Ilumina Go Mini Grant challenge for her research investigating the utility of next generation sequencing in breast cancer predisposition testing.

Breast Cancer Research is proud to have funded Úna’s work on this innovative project. Úna was one of 1,100 international entries for the award, she is photographed here collecting her award at the American Association of Cancer Research Meeting in New Orleans on Monday 18 April.

Check out the press coverage on Úna’s award in Irish Tech News, The Journal.ie, and Silicon Republic.


 

Professor Michael Kerin and Dr Laura Barkley were awarded a Breast Cancer Now Pilot grant to study “The role of stromal and epithelial Syndecan-2 in breast tumour development”.

Dr Roisin Dwyer, Lecturer in Translational Science, was invited to the Aras to represent NUI Galway as part of a Women in Science initiative. Roisin leads several of the projects funded by Breast Cancer Research.

Dr Doireann Joyce won the runner-up oral presentation prize at the 2nd annual Matrix Biology Ireland meeting in Dec 2015 for her work entitled “Breast cancer-derived exosomes stimulate proliferation of stromal cells in the tumour microenvironment


Breast Cancer Research Summer Research Students

NUI Galway undergraduate summer research students funded by Breast Cancer Research presented their research findings at the School of Medicine Undergraduate Research Day on 4 February at the Clinical Science Institute, NUI Galway.

From left to right: Dr Róisín Dwyer (Lecturer In Translational Science and Chair of the Undergraduate Research Committee, NUI Galway), Anuar Ramli, Aisling McNamara, Maeve Cahalan, Lewis Callaghan, Professor Tim O’Brien (Dean of the College of Medicine, Nursing and Health Sciences at NUI Galway and Director, Board of Directors of Breast Cancer Research), Niamh O’Flaherty, John Bourke, Christine Costelloe (Development Director of Breast Cancer Research), Professor Michael Kerin (Director of Lambe Institute for Translational Research and Research Director of Breast Cancer Research), Stephen O’Brien, Conor Palmer (not pictured).


 

Breast Cancer Research-100Partially funded by a €1 million donation from Breast Cancer Research, the research team moved into a purpose-built laboratory facility in 2015.

The Lambe Institute for Translational Research is home to over 50 cancer researchers. The facility is located on the campus of University Hospital Galway and the breast research laboratory is affiliated with the hospital’s Symptomatic Breast Centre, the busiest breast clinic in the country. As a result, it is ideally positioned for collaboration with university and clinical experts.


ACSR Conf UL 109

John Bourke is pictured 3rd from right with Dr Roisin Dwyer, 2nd from right at the UL Medical School

Each year over 70 medical students at NUI Galway undertake short research projects, usually 6-8 weeks over the summer.

Core research areas for 2015 included; circulating microRNAs in breast cancer, breast cancer genetics, exosomes in breast cancer, tumour intracellular communication, breast cancer imaging techniques, gene therapeutics using mesenchymal stems cells, and clinical breast cancer management.

John Bourke, a 4th year student, worked with Dr Doireann Joyce and Dr Roisin Dwyer and went on to win the poster prize at the 2nd Annual Atlantic Corridor Research Conference at the University of Limerick in October 2015. This conference brings together undergraduate research students from UL, UCC and NUI Galway.


 

Washington DC NCI course_2015

Dr Doireann Joyce and Dr Maire Caitlin Casey (Pictured front row 1st and 2nd from left)

Two PhD researchers, Dr Doireann Joyce and Dr Maire Caitlin Casey, were awarded scholarships to attended a “Molecular Prevention Course” at the National Cancer Institute, Washington DC, in August 2015.

 

 

 

 


 

A Selection of Recent Research Publications

Exploring circulating microRNA in the Neoadjuvant Treatment of Breast Cancer.
Casey MC, Sweeney KJ, Brown JAL, Kerin MJ. Int J Cancer. 2016 Jan 12.

A qualitative analysis of the attitudes of Irish patients towards participation in genetic-based research. McVeigh TP, Sweeney KJ, Kerin MJ, Gallagher DJ. Ir J Med Sci. 2015 Oct 23.

Cross Platform Standardisation of an Experimental Pipeline for Use in the Identification of Dysregulated Human Circulating MiRNAs. Kelly H, Downing T, Tuite NL, Smith TJ, Kerin MJ, Dwyer RM, Clancy E, Barry T, Reddington K. PLoS One. 2015 Sep 10;10(9):e0137389.

Height and Breast Cancer Risk: Evidence From Prospective Studies and Mendelian Randomization. Zhang B,….,Kerin MJ, Miller N et al. J Natl Cancer Inst. 2015 Aug 20;107(11).

Effects of age on the detection and management of breast cancer. McGuire A, Brown JA, Malone C, McLaughlin R, Kerin MJ. Cancers (Basel). 2015 May 22;7(2):908-29.

Estrogen withdrawal, increased breast cancer risk and the KRAS-variant. McVeigh TP, Jung SY, Kerin MJ, Salzman DW, Nallur S, Nemec AA, Dookwah M, Sadofsky J, Paranjape T, Kelly O, Chan E, Miller N, Sweeney KJ, Zelterman D, Sweasy J, Pilarski R, Telesca D, Slack FJ, Weidhaas JB. Cell Cycle. 2015;14(13): 2091-9.

MicroRNA-10a is reduced in breast cancer and regulated in part through retinoic acid. Khan S, Wall D, Curran C, Newell J, Kerin MJ, Dwyer RM. BMC Cancer. 2015 May 2;15:345.

 

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